Accurate Protein Aggregation Analysis by Multi-Laser Nanoparticle Tracking
Protein aggregation is an important concern when developing and manufacturing biotherapeutics since subvisible aggregate particles have been associated with the adverse drug reactions. Therefore, it is important to quantify protein aggregation and particle formulation due to various stresses. In this white paper, we demonstrate with case studies on how multi-laser nanoparticle tracking analysis (NTA) approach allows polydisperse samples and much larger range of particle sizes to be visualized.

The HORIBA Group of worldwide companies provides an extensive array of analytical instruments. Included in the Scientific segment are Raman and Fluorescence spectrometers, ICP-OES, particle characterization and elemental analyzers. The particle characterization has a line up of particle size analyzers that measure from nanometers to millimeters, particle shape, zeta potential, surface area, and nanoparticle tracking.