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Diagnostics World | A team of researchers from Institute of Science Tokyo, Japan, are using nanowires with machine learning analysis to detect cancer-associated miRNAs in urine. Their research findings were published last month online in Analytical Chemistry.
Nov 19, 2024
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Diagnostics World | Placental pathology has potential to reveal critical insights into pregnancy complications, yet it remains underutilized in clinical trials. By incorporating placental evaluations into clinical research, doctors could better understand and treat conditions like preeclampsia and preterm birth, which are currently diagnosed based only on clinical signs.
Nov 15, 2024
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Diagnostics World | Researchers in Israel recently showcased a novel platform that can be used in the future for the early diagnosis of Parkinson’s disease (PD) by quantifying the distribution of alpha-synuclein (α-syn) in skin biopsies. A proof-of-concept study in humans, supported in part by the Michael J. Fox Foundation, suggests the single-molecule-level detection method might enable the disease to be detected up to 20 years before the first motor symptoms appear.
Nov 13, 2024
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Diagnostics World | Recent years have seen progress toward developing tools that are designed to analyze a human breath sample to detect, diagnose, or monitor various health issues. Some of these efforts have focused on combating deadly infectious diseases, with intentions of creating cost-effective, easy-to-use breathalyzers capable of being deployed in rural, remote, and low-resource settings.
Nov 12, 2024
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Diagnostics World | A next-generation liquid biopsy approach combining cell-free DNA (cfDNA) “fragmentome” and protein biomarker analyses could aid in the early detection of ovarian cancer, suggests a recent study by researchers in the U.S., The Netherlands, and Denmark. The DELFI-Pro classifier was found to have a high positive predictive value, a key accuracy metric.
Nov 7, 2024
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Diagnostics World | A diagnostic test invented at the University of Arizona has demonstrated its potential to predict the likelihood of relapse or recurrence among patients with early-stage breast cancer and their response to antifibrotic therapy. The tool, known as MeCo Score, measures metastatic risk based on the acclimation of cancer cells to the mechanical stiffness of tissue (fibrosis) as computed from RNA sequencing data on tumor samples.
Nov 4, 2024
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Diagnostics World | In another few years, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) analytes may be “obsolete” because the famously bad and good guys in standard cholesterol tests provide less useful information about heart health than other lipid molecules circulating in the blood. The evidence emerges from a recent study in children and adolescents with overweight or obesity finding a new relationship between lipids and diseases impacting metabolism.
Oct 31, 2024
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Diagnostics World | Revvity launches the in vitro diagnostic EURORealTime APOE assay in European countries that accept the CE mark; Withings Health Solutions announces a first-of-its-kind cellular blood pressure monitor; and more.
Oct 30, 2024
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Diagnostics World | Cytovale plans to commercially expand IntelliSep, the company’s sepsis diagnostic test, to more hospital emergency departments and health systems nationwide; C2N Diagnostics will continue to develop their next-generation tests specific to tau tangle pathology; and more.
Oct 29, 2024
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Diagnostics World | Owkin and AstraZeneca announced a new partnership this month to develop an AI-powered tool to pre-screen for germline BRCA (gBRCA) mutations in breast cancer directly from digitized pathology slides. As part of Owkin’s ongoing collaboration with Gustave Roussy and The Centre Léon Bérard through PortrAIt, a French consortium to accelerate precision medicine through AI-enabled digital pathology, this tool aims to significantly accelerate and expand access to gBRCA testing that too many patients may not be considered for.
Oct 25, 2024
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Diagnostics World | Dr. Jae-Hyun Ryou, a mechanical engineer at the University of Houston, has developed a breakthrough wearable eye-tracking system aimed at enhancing brain studies through continuous monitoring. The flexible piezoelectric eye movement sensor array (F-PEMSA) consists of three small sensors, each smaller than a penny, which attach comfortably to the upper, mid, and lower temple.
Oct 16, 2024
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Diagnostics World | As the departments of Defense and Homeland Security are acutely aware, national security and human health have a lot of crossover, including biothreats and infectious diseases. Their investment in instrumentation for rapid analysis of biologic aerosols in the late 1990s is now being creatively repurposed by engineers at Zeteo Tech, together with some novel breath sampling techniques, for the early detection of respiratory infections.
Oct 15, 2024
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Diagnostics World | Recent studies from researchers at Imperial College London have demonstrated how AI can identify patients with significantly higher risk of experiencing major adverse cardiac events (MACE), including heart attacks and heart failure, and how such a tool can be incorporated into the clinic.
Oct 8, 2024
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Diagnostics World | It is no surprise that clinical trial sponsors are slowly embracing new tools and technologies to achieve greater levels of precision and efficiency needed in an increasingly demanding and competitive drug discovery and development landscape. Where there was once hesitation due to the unknowns of straying from historical analytic processes, there has been exponential growth in the application of digital pathology within clinical research and development efforts in recent years.
Oct 4, 2024
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Diagnostics World | Proscia yesterday launched Concentriq Embeddings for whole slide images and the Proscia AI Toolkit, a collection of tutorials and functions to help teams rapidly integrate Concentriq Embeddings into their workflows.
Oct 3, 2024
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Diagnostics World | In a first for genetic diagnostics, a pair of Nobel-Prize-winning technologies are being repurposed for obtaining RNA from disease-causing genes that are expressed in neither blood nor skin. The feat comes from the Neurobiology Research Group at the University of Adelaide’s School of Biomedicine, led by Lachlan Jolly, Ph.D., which aims to resolve the pathogenicity of 300 variants of uncertain significance (VUSs) under a government-funded, Australia-wide study.
Oct 1, 2024
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Diagnostics World | Inflammatix plans to get its lead product, the TriVerity Acute Infection and Sepsis Test (TriVerity), out to market; Syantra aims to commercialize its first test on its patent-pending platform for early detection of breast cancer; and more.
Sep 26, 2024
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Diagnostics World | QIAGEN has entered a collaboration with Eli Lilly to support the development of a QIAstat-Dx in-vitro diagnostic (IVD) to detect APOE genotypes; Illumina welcomed the European Court of Justice's judgment ruling that the European Commission did not have jurisdiction over Illumina's acquisition of GRAIL; Ambry Genetics announced enhancements to their portfolio of tests for the detection of genetic mutations associated with hereditary cancer; and more.
Sep 25, 2024
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Diagnostics World | Researchers at the Mayo Clinic have developed a new tool that uses machine learning to analyze a stool sample to provide insights into your gut health. The tool, called the Gut Microbiome Wellness Index 2 (GMWI2), can detect subtle changes in the gut to see if one is progressing toward better health or possibly developing a disease.
Sep 19, 2024
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Diagnostics World | The push in personalized medicine to look beyond the genome has netted quite a few valuable ‘omics technologies. Linus Bio is tracking environmental exposures recorded over time in hair. Manish Arora, CEO and founder of LinusBio, believes the platform will “revolutionize personalized medicine.”
Sep 18, 2024