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Diagnostics World | Karius plans extend its reach beyond the 400 U.S. hospitals currently using the Karius Test, an infectious disease diagnostic test that utilizes genomic analysis and artificial intelligence to detect over 1,000 pathogens from a single blood sample; PinkDx launches to pursue its vision of identifying unmet medical needs that are unique to women; En Carta develops a point-of-care diagnostic for Lyme disease; more.
May 28, 2024
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Diagnostics World | Using an artificial intelligence (AI) model that was trained on millions of variants from identified genetic disorders and incorporates the complex decision-making process of human molecular scientists, investigators at Baylor College of Medicine are on track to automate the diagnosis of an enormous number of undiagnosed conditions.
May 23, 2024
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Diagnostics World | Researchers at the University of Michigan (U-M) have developed a urine test for prostate cancer known as MyProstateScore 2.0 (MPS2), now a property of spinoff LynxDx, which they expect to significantly improve upon the performance of existing assays by focusing on clinically significant cancers and capturing more biomarkers in a single test.
May 21, 2024
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Diagnostics World | Science and technology have moved up the appearance of a high-performance point-of-care mass spectrometer to a near-term possibility, which would make it both cheaper and more convenient to monitor chronic health conditions from just about anywhere a 3D printer could be deployed—including the jungle, Antarctica, and future colonies on Mars.
May 16, 2024
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Diagnostics World | The lab of W. Andy Tao, professor of biochemistry at Purdue University, is pioneering a way to assess drug response based on metabolizing proteins found in circulating extracellular vesicles (EVs), which could serve as a surrogate of their expression level in the liver and become therapeutic targets for some cancers.
May 15, 2024
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Diagnostics World | A cancer researcher at Florida International University (FIU) has developed a functional precision medicine (FPM) approach to oncology treatment decision-making that combines genomic profiling with drug sensitivity testing on patient-derived tumor cells. Children with relapsed or refractory cancers are among the initial beneficiaries.
May 14, 2024
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Diagnostics World | Every resource in healthcare is precious. The last few years have tested healthcare systems in almost every way, with significant impacts on their long-term financial health and, by extension, the quality of care they can provide. A 2023 report by the American Hospital Association estimates that overall hospital expenses rose by 17.5% between 2019 and 2022.
May 10, 2024
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Diagnostics World | In oncology, it is well appreciated that time is life. Diagnostics are therefore valuable not just to determine the disease state of patients but how best to treat them, says Jane Li, senior director of oncology, pharma, and CRO partnerships related to clinical sequencing at Thermo Fisher Scientific.
May 7, 2024
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Diagnostics World | A much-anticipated rule to regulate laboratory developed tests (LDTs) as medical devices has arrived, with significant implications for the diagnostic industry and patient care. Here’s a closer look at the historical context underlying the new rule, the debate leading up to this moment, recent updates, and the road ahead.
May 2, 2024
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Diagnostics World | Significant evidence now exists implicating the Epstein-Barr virus (EBV) as a causal factor in the development of multiple sclerosis (MS), making treatment of the virus a priority. To that end, research scientists at Trinity College Dublin have developed a blood test to measure the immune response to EBV that could be used as an outcome measure in future clinical trials in people with established MS.
May 1, 2024
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Diagnostics World | Researchers at the University of Chicago have succeeded in creating a digital twin of the gut microbiome of premature infants that reliably models the many interactions taking place between quickly changing bacterial inhabitants. The so-called “Q-net” model, created with generative artificial intelligence (AI), was used to make predictions about which infants were going to have neurodevelopmental deficits using head circumference as the proxy.
Apr 30, 2024
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Diagnostics World | Roche will distribute Prenosis’s Sepsis ImmunoScore, an artificial intelligence/machine learning software as a medical device to guide rapid diagnosis of sepsis and prediction of adverse outcomes; PathAI announced a strategic partnership with Google Cloud at Bio-IT World Conference & Expo to help biopharma companies and anatomic pathology labs accelerate the adoption of AI and digital pathology; more.
Apr 25, 2024
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Diagnostics World | Asher Therapeutics will advance the clinical development of its lead program, AB248, a novel CD8+ T cell selective IL-2, generated by fusing a reduced potency IL-2 mutein to an anti-CD8β antibody; Kryptos Biotechnologies will further develop Kryptos’s flagship point-of-care molecular diagnostics system Kuick and advance the clinical study of the respiratory combo tests; DeepCure plans to advance its generative AI and physics-based engine to innovate the discovery of small molecule therapies for challenging targets; more.
Apr 24, 2024
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Diagnostics World | Researchers in Denmark have devised a blood-based diagnostic technique that can detect even trace amounts of an aggregated protein indicative of Alzheimer’s disease before any disease-related changes show up on a PET scan, one of the traditional testing methods. The same technology can be used for developing new therapies by revealing what part of the innate immune system is engaged in the fight.
Apr 18, 2024
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Diagnostics World | Minimal residual disease testing (MRD) has been gaining ground in diagnostics, and a panel took on the topic at the Precision Medicine TriCon late last month.
Apr 17, 2024
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Diagnostics World | At the Precision Med TriConference 2024, Illumina Ventures partner Mara Aspinall sat with Eric Topol, endowed chair and executive VP and professor at Scripps Translational Science Institute, in a fireside chat to discuss precision medicine and artificial intelligence (AI). With three published books and more than 1,200 peer reviewed publications, Topol is one of the industry’s leading minds on digital medicine, and from his perspective, AI needs to be adapted sooner.
Apr 16, 2024
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Diagnostics World | As the body’s stress hormone, cortisol influences several diseases, from chronic illnesses, such as diabetes and cancer; to mental illnesses, such as depression; to neurological diseases, such as Alzheimer’s disease. Researchers at Aarhus University have discovered a breakthrough method to measure cortisol in an efficient, faster way.
Apr 11, 2024
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Diagnostics World | During the NVIDIA GTC conference held at the San Jose Convention Center and online March 18-21, NVIDIA CEO Jensen Huang highlighted an array of advancements, including new foundation models coming to NVIDIA BioNeMo, a collaboration with Johnson & Johnson MedTech to expand AI’s role in surgical settings, and the launch of over two dozen generative AI microservices to advance areas like digital health, medical technology, and drug discovery.
Apr 9, 2024
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Diagnostics World | A wearable device measuring movement at the wrist can detect clear differences in people who do and don’t have beta-amyloid deposition in their brain. The discovery was enabled by a relatively new statistical technique revealing time-of-day changes in activity levels not captured by standard methods focused on average levels of activity across the day.
Apr 4, 2024
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Diagnostics World | Study sponsors making choices about if, when, and how to include brain monitoring in their clinical studies do not often ground those choices in science or optimize for subject safety and trial de-risking. The key problem is a lack of electroencephalogram (EEG) expertise with no guidance from the Food and Drug Administration (FDA) to mitigate the situation.
Apr 3, 2024