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New Pathology Foundation Models, Tutorials for Whole Slide Images

By Diagnostics World News Staff 

October 3, 2024 | Proscia yesterday launched Concentriq Embeddings for whole slide images and the Proscia AI Toolkit, a collection of tutorials and functions to help teams rapidly integrate Concentriq Embeddings into their workflows.  

Part of the Concentriq platform, Concentriq Embeddings delivers a collection of pathology foundation models to AI developers and research scientists, allowing them to leverage their organization’s large proprietary datasets and execute models in routine workflows. 

“It’s an exciting time at the intersection of medicine and technology. The proliferation of digital pathology and explosion in capabilities of today’s AI models bring a totally new scale to how to develop therapies and diagnose patients,” said David West, CEO of Proscia, in a press release. “We’re approaching a world where experiments that once took years can now be run in silico in a matter of days, and life-saving treatments that reach only a fraction of patients today could soon reach everyone.” 

Updates to AI Development in Pathology 

Concentriq Embeddings allows pathology and data science teams to generate high-dimensional numerical representations—embeddings—from whole slide images. These embeddings are initially derived from four powerful foundation models—DINOv2, PLIP, ConvNext, and CTransPath—with plans to continuously add new models as they evolve. This ensures that researchers always have access to the latest state-of-the-art tools and can experiment with multiple models in parallel, which further enhances downstream performance and improves the accuracy of biomarker discovery and other critical tasks.  

Researchers can also select the best foundation model for their specific needs, with applications ranging from image classification and segmentation to risk scoring and multimodal data integration, supporting rapid prototyping and large-scale AI model development directly within the Concentriq platform. The platform is further enriched by Proscia’s real-world data (RWD) offering, providing access to high-quality, diverse multimodal datasets that empower researchers to build more accurate and clinically viable AI models. 

During pilot programs with a top CRO and a top pharmaceutical company, Concentriq Embeddings demonstrated its ability to significantly accelerate AI development. In one internal case study, data scientists developed algorithms 13x faster, generating 80 AI-based breast cancer biomarker prediction models in under 24 hours. In a production setting, pharmaceutical companies can reduce AI development time from weeks to hours—allowing therapies to reach patients much sooner. 

Proscia AI Toolkit: Accelerating AI Adoption 

To complement Concentriq Embeddings, Proscia is introducing the Proscia AI Toolkit—a suite of open-source resources designed by Proscia’s AI R&D team to empower the life sciences community and accelerate AI adoption. 

The Proscia AI Toolkit includes: 

  • A Python client for seamless API integration with Concentriq Embeddings.
  • Comprehensive tutorials paired with Python code in Jupyter Notebooks, enabling users to learn and implement AI quickly.
  • A growing library of helper functions for tasks like image tiling and organizing API outputs, reducing the complexity of common processes. 

These resources are designed to help teams rapidly integrate Concentriq Embeddings into their workflows, allowing them to focus on building and refining AI models instead of navigating technical hurdles. Moreover, the growing community of Concentriq users is encouraged to contribute their own tools, expanding the library with new techniques and innovations. This collaborative, community-driven approach will not only enhance the implementation of foundation models but also broaden the use of AI—whether building, visualizing, or deploying models—across the Concentriq platform. 

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