The Hollow Fiber Model: In Vivo Screening Assay to Speed Up Your Drug Discovery Process
When a drug discovery project enters the phase of in vivo testing many questions arise: “How reliable is our in vitro data? Did we choose the right lead compounds? Which is the best tumor model to use for in vivo efficacy testing?” The Hollow Fiber Model is an in vivo drug screening assay bridging the gap between in vitro and in vivo testing of anticancer agents allowing for rapid answers regarding drug efficacy with simultaneous evaluation of pharmacokinetic and pharmacodynamic parameters.