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Diagnostics World | Minimal residual disease testing (MRD) has been gaining ground in diagnostics, and a panel took on the topic at the Precision Medicine TriCon late last month.
Apr 17, 2024
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Diagnostics World | At the Precision Med TriConference 2024, Illumina Ventures partner Mara Aspinall sat with Eric Topol, endowed chair and executive VP and professor at Scripps Translational Science Institute, in a fireside chat to discuss precision medicine and artificial intelligence (AI). With three published books and more than 1,200 peer reviewed publications, Topol is one of the industry’s leading minds on digital medicine, and from his perspective, AI needs to be adapted sooner.
Apr 16, 2024
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Diagnostics World | As the body’s stress hormone, cortisol influences several diseases, from chronic illnesses, such as diabetes and cancer; to mental illnesses, such as depression; to neurological diseases, such as Alzheimer’s disease. Researchers at Aarhus University have discovered a breakthrough method to measure cortisol in an efficient, faster way.
Apr 11, 2024
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Diagnostics World | During the NVIDIA GTC conference held at the San Jose Convention Center and online March 18-21, NVIDIA CEO Jensen Huang highlighted an array of advancements, including new foundation models coming to NVIDIA BioNeMo, a collaboration with Johnson & Johnson MedTech to expand AI’s role in surgical settings, and the launch of over two dozen generative AI microservices to advance areas like digital health, medical technology, and drug discovery.
Apr 9, 2024
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Diagnostics World | A wearable device measuring movement at the wrist can detect clear differences in people who do and don’t have beta-amyloid deposition in their brain. The discovery was enabled by a relatively new statistical technique revealing time-of-day changes in activity levels not captured by standard methods focused on average levels of activity across the day.
Apr 4, 2024
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Diagnostics World | Study sponsors making choices about if, when, and how to include brain monitoring in their clinical studies do not often ground those choices in science or optimize for subject safety and trial de-risking. The key problem is a lack of electroencephalogram (EEG) expertise with no guidance from the Food and Drug Administration (FDA) to mitigate the situation.
Apr 3, 2024
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Diagnostics World | You might be forgiven for calling the tone of a panel on diagnostics held at last week’s Precision Medicine Tri-Con “optimistic”. But you would be corrected: it isn’t optimism, it’s math.
Apr 2, 2024
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Diagnostics World | Capstan Therapeutics is advancing CPTX2309, their lead in vivo chimeric antigen receptor T cell (CAR-T) candidate, to early clinical proof-of-concept in autoimmune disorders; Clasp is developing modular T cell engagers tailored to each patient’s immune system that are directed to common oncogenic driver mutations; X-Therma plan to scale global commercial operations and facilitate progression into the clinical stage with FDA Breakthrough Device status, aimed at significantly increasing organ availability for transplantation by overcoming time-sensitive limitations; and more.
Mar 27, 2024
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Diagnostics World | Capstan Therapeutics is advancing CPTX2309, their lead in vivo chimeric antigen receptor T cell (CAR-T) candidate, to early clinical proof-of-concept in autoimmune disorders; Clasp is developing modular T cell engagers tailored to each patient’s immune system that are directed to common oncogenic driver mutations; X-Therma plan to scale global commercial operations and facilitate progression into the clinical stage with FDA Breakthrough Device status, aimed at significantly increasing organ availability for transplantation by overcoming time-sensitive limitations; and more.
Mar 26, 2024
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Diagnostics World | The single biggest risk factor for autoimmune disease is being biologically a female and many explanations have been proposed as to why that is, among them sex hormones and the X chromosome with its large number of immune-related genes.
Mar 21, 2024
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Diagnostics World | When it comes to research on amyotrophic lateral sclerosis (ALS), every stakeholder—most especially patients—knows time is of the essence. From diagnosis to death, life expectancy from the debilitating neuromuscular disease can be two years or less.
Mar 20, 2024
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Diagnostics World | Scientists in the Georgia Tech Integrated Cancer Research Center (ICRC) are proposing a new, more realistic approach to diagnosing cancer that provides a probabilistic statement about the likelihood of developing it, much like how cholesterol tests are used to assess heart disease risk. Probabilities are based on an individual’s metabolic profile and the first population group to be targeted are women at high risk for ovarian cancer.
Mar 19, 2024
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Diagnostics World | Scientists from a trio of countries are calling for a new, more comprehensive way of classifying Parkinson’s disease for diagnostic research purposes that considers an individual’s biology. The disorder might thereby be detected before patients have any symptoms, as is now the case for cancer and diabetes.
Mar 14, 2024
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Diagnostics World | For roughly half of patients with recurrence of often-deadly glioblastoma multiforme (GBM), their tumors are characterized by cells that look a lot like healthy neurons. The mimicry trick was discovered by proteomics, which has opened a view to tumor alterations unavailable through genetics alone.
Mar 12, 2024
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Diagnostics World | Biomedical engineers have a significant role to play in the development and optimization of liquid biopsies to further precision oncology. Although molecular profiling of tumors has entered mainstream clinical practice, the wait time for identifying the best treatment for individual patients could be shortened by blood-testing devices designed to efficiently capture circulating tumor cells (CTCs) and cancer-specific protein markers on their surface.
Mar 7, 2024
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Diagnostics World | A team of researchers from Massachusetts Institute of Technology (MIT) and the Broad Institute of MIT and Harvard are developing priming agents to temporarily boost levels of cell-free DNA (cfDNA) for cancer diagnostics. It’s an entirely new concept that could do for liquid biopsies what contrast agents have done for ultrasound and MRI.
Mar 6, 2024
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Diagnostics World | A machine learning method dubbed A-PLUS (Alu Profile Learning Using Sequencing) recently demonstrated its ability to pick up cancers earlier and with smaller blood draws than is required for whole genome sequencing. This makes possible a future where people might get annual blood draws to check for cancer based on the “fragmentation pattern” of cell-free DNA (cfDNA) circulating in their blood.
Mar 5, 2024
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Diagnostics World | Owkin-Amazon Web Services partner on AI-assisted diagnostics, Diagnexia announced a significant collaborative agreement with Aga Khan University Hospital (AKUH), Nairobi; X-trodes announced that the U.S. Food and Drug Administration has granted 510(k) clearance for X-trodes' Smart Skin solution (marketed as X-trodes System M); PathAI has announced an expanded and exclusive relationship with Roche Tissue Diagnostics (RTD) that will bring AI-enabled interpretation to companion diagnostics; and more.
Feb 29, 2024
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Diagnostics World | Freenome will advance the pipeline of single-cancer and tailored multi-cancer early detection tests built on its multiomics platform; Capitainer will continue its journey toward becoming the foremost provider of self-sampling solutions with new funding; Circular Genomics plans to build and scale commercial operations in preparation for the launch of the world's first circular RNA-based clinical assay; and more.
Feb 28, 2024
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Diagnostics World | Among the sequencing news at AGBT earlier this month, Ultima Genomics announced the commercial launch of its UG 100 ultra-high throughput sequencing platform.
Feb 27, 2024